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& Strittmatter, P
In this same study, older age, not sex, was associated with the risk of acute liver failure
By modifying the primary sequence of OXM and linking to the constant region of human IgG4, Jung and colleagues demonstrated their peptide HM12525A had a potent and balanced activity at both GLP-1 and glucagon receptors in vitro and led to body weight loss of 30% in DIO mice over 14 days compared to liraglutide treated mice (74)
Studies have shown that significant concentrations of lixisenatide were found in the brain of mice 30 minutes and 3 hours after intraperitoneal injection, suggesting that lixisenatide could cross the BBB (125)
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