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Unsaturated fatty acids under conditions of oxidative stress form highly reactive epoxides resulting in formation of protein adducts (124), which also increase ER stress (125)

30-Second Takeaway Supplementing with glutathione, an antioxidant that neutralizes free radicals, is generally safe

The brain's high metabolic demands and vulnerability to oxidative stress make glutathione particularly crucial for maintaining healthy neurological function, and the enhanced bioavailability of this modified form supports superior cellular protection compared to traditional glutathione supplementation [5]