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Given the compounds increasing availability, popularity, and its regulatory controversies, we sought to assess the breadth and quality of preclinical and clinical data supporting its use in musculoskeletal medicine
It activates antioxidant enzymes such as superoxide dismutase (SOD), promotes collagen and elastin synthesis, and suppresses fibrotic pathways by inhibiting TGF-?1 signaling
A 150-pound and a 250-pound patient typically use similar doses because the mechanism is signaling-based rather than concentration-based
Calculations are shown for both the 5 days/week and 3 times/week schedules
Starting with Short Intervals and Flat Surfaces Begin with 5-10 minute walks on level ground
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