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Reduce caloric intake pharmacologically, and NEAT (non-exercise activity thermogenesis) drops by 200400 calories per day within weeks

NAD precursors (nicotinamide riboside, nicotinamide mononucleotide) work by directly supplying building blocks for NAD synthesis

It might be an enzyme you have never heard of, one that is actively working against your fat loss efforts at the cellular level

The result is a vicious cycle where declining NAD+ leads to worse metabolic function, which can lead to weight gain, which increases NNMT activity further

There is no human head-to-head bioavailability trial declaring one route superior, so pick the route your protocol specifies and hold it consistently