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The modified biotin switch method is based on the assumption that methyl methanethiosulfonate (MMTS) selectively blocks thiols over persulfides, which, however, has been questioned a number of times on chemical grounds ( 38 , 39 )

These nanoparticles can be engineered to specifically target cardiac, vascular, or neuronal mitochondria, enabling more efficient and targeted delivery of therapeutic agents

Whether similar trigger-wave dynamics can be sustained in complex three-dimensional tissues, where geometry, extracellular matrix, and heterogeneous antioxidant buffering may substantially alter propagation behavior, remains an important open question and a critical test of the models physiological generalizability

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GHK-Cu is the biologically-active form where GHK is complexed with a copper(II) ion