Cosmeceuticals and Cosmetic Practice
Collagen Organization : Studies indicate improved collagen fiber alignment, which supports structural integrity in healing tendons
A licensed provider can recommend the best schedule
10 mg Vial Reconstitution BAC water added 2 mL Concentration 5,000 mcg/mL 250 mcg dose volume 0.05 mL = 5 units 500 mcg dose volume 0.10 mL = 10 units Doses per vial at 250 mcg 40 BAC water added 3 mL Concentration 3,333 mcg/mL 250 mcg dose volume 0.075 mL = ~7.5 units 500 mcg dose volume 0.15 mL = 15 units Doses per vial at 250 mcg 40 Units shown are U-100 insulin syringe units (where 100 units = 1.0 mL)
This may be due to copper's ability to enhance the expression of metalloproteinases (MMPs).16 MMPs normally regulate the degradation of collagen, and a specific one, MMP-1, may be responsible for the initiation of collagen fragmentation.17 Supporting this, a 2024 study noted that elevated MMP-1 levels appear to contribute to aging skin and that higher MMP-1 levels in mice led to:18 The loss and fragmentation of dermal collagen fibrils Contracted fibroblast morphology Reduced collagen production Increased expression of pro-inflammatory mediators Additionally, a 2016 study found that GHK-Cu significantly increased gene expression of MMP-1 and MMP-2 at the lowest concentration, which the studys authors considered to be one of the reasons the peptide was able to increase collagen and elastin production.19 So, what this could ultimately mean is that using too much GHK-Cu (or other copper peptides) may in theory increase the skins MMP-1 concentration above the levels involved in healthy collagen production, taking it into the collagen fragmentation and breakdown territory seen in older skin with naturally higher MMP-1 levels
