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2 The immunotherapeutic landscape of osteosarcoma: challenges and resistance mechanisms 2.1 The immunosuppressive TME The osteosarcoma TME is a complex ecosystem comprising malignant cells, stromal cells, immune infiltrates, and ECM components embedded within a mineralized bone scaffold ( TAMs represent the most abundant immune cell population within the osteosarcoma TME, often accounting for over 50% of infiltrating immune cells ( MDSCs constitute another major immunosuppressive population in the osteosarcoma TME

Think of amino acids as the letters of an alphabet and mix those letters together, you get a peptide that delivers a highly specific message to the cell

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Med Hypotheses 2005