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Table 2: Microbial metabolites: their synthesis, mechanisms of action, and effects on health and disease Figure 1: Molecular mechanisms of action of indole and its metabolites on host physiology and disease 1 2 "Trace amine-associated receptors: ligands, neural circuits, and behaviors"

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Recently, a new definition of NAFLD was suggested by a panel of international experts: Metabolic Associated Fatty Liver Disease (MAFLD), which contains positive criteria and is independent of alcohol use to diagnose the disease [1]

Flavincontaining monooxygenases catalyze an NADPH- and an oxygen-requiring oxidation of substances (primarily xenobiotics) bearing functional groups containing nitrogen, sulfur, or phosphorus