When they do occur, most often they will lessen or disappear over time, as your body adjusts to the medication
In animal models, findings suggest stronger responses in obese specimens compared to lean ones
For some people, semaglutide diarrhea after eating is a frequent early complaint
Metoclopramide and erythromycin are the two most commonly used agents used to manage gastroparesis and there is potential that the GLP-1 agonists will oppose the prokinetic effects of these agents Corticosteroids Corticosteroids are notorious for raising blood sugars which could directly oppose the blood sugar lowering effects of GLP-1 agonists
sarcopenia risk in older adults Refeeding syndrome risk in patients who are already nutritionally compromised Psychiatric Signals: What We Know and Do Not Know The largest psychiatric safety meta-analysis to date 80 randomized controlled trials, over 107,000 patients found that GLP-1 medications were not associated with increased risk of serious psychiatric adverse events overall, including suicidal ideation (Pierret et al., JAMA Psychiatry, 2025)
