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While IGF-1 has important physiological functions, elevated levels carry potential concerns including increased cell proliferation that may support tumor growth in individuals with cancer or pre-cancerous conditions, accelerated aging processes through growth pathway activation, potential cardiovascular effects with chronic elevation, and metabolic consequences including effects on glucose and lipid metabolism

Lipidated or PEGylated peptides often dissolve slowly and may need longer incubation or a small organic cosolvent

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The compound has a four-amino-acid sequence Alanine-Glutamic acid-Aspartic acid-Glycine (AEDG) of the parent peptide

Poor respiration and fatalities were not observed (Duplancic et al., 2014)