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discovered that choline, phosphatidylcholine, L-carnitine, and betaine, which are dietary components, undergo metabolism by gut microbiota resulting in the production of Trimethylamine (TMA)

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In addition, the carnitine pool influences the metabolic process of branched-chain amino acids (BCAAs)

Innovative diagnostic technologies, such as the use of nanophotonic metasurfaces (Ye et al., 2024) and fluorescence polarization-based aptasensors (Zhang et al., 2023b), have been developed to detect LF in tear fluid, offering new approaches for accurate DED diagnosis and classification