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Consequently, the metabolic pathways initiated by G proteins within GLP-1R involve cAMP activation, extracellular signal-regulated kinases 1 and 2 (ERK 1/2) and increased intracellular calcium levels (17, 19)
The glucose-dependent mechanism substantially reduces hypoglycemia risk compared to sulfonylureas or insulin, making these agents particularly suitable for older adults or those at high hypoglycemia risk
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