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In some cases, the intracellular Ca 2+ binds to calmodulin (CAM), which further binds to the Ca + /calmodulin-dependent protein kinase II (CAMKII) and phosphorylates the AMPA receptor on the synaptic membrane, resulting in increased Na + conductance

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Future research must therefore pivot toward integrated, multi-targeted nutritional strategies that simultaneously address these interconnected pathways, moving beyond single-nutrient approaches to achieve personalized OA management (35)