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This triggers downstream signaling pathways (e.g., NF-B and MAPK), driving the massive release of pro-inflammatory cytokines, including IL-1, IL-6, and TNF- (167170)

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Morgastrern et al., 2018), Tg2576 (Alexander et al., 2011), 3xTg (Zhang et al., 2022) and rTg4510 (Jul et al., 2015), males exhibit significant aggressive behavior compared to wild-type mice, as assessed by the resident-intruder test