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Genetics and behavioral factors significantly influence individual outcomes
10.1038/s41575-020-00372-7 47 KumadaH
The -synuclein aggregates specifically bind to the translocase of outer mitochondrial membrane (TOMM) 20, significantly inhibiting the transmembrane transport of mitochondrial precursor proteins, ultimately leading to mitochondrial dysfunction in dopaminergic neurons [96]
The more aggressive the deficit, the worse the lean-mass ratio a slower titration and a moderate deficit protect muscle better than crash-style loss
You compensate by taking more, which compounds the GI risk
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