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CD36 promotes NLRP3 inflammasome activation via the mtROS pathway in renal tubular epithelial cells of diabetic kidneys
Increasing the dose of exenatide is not recommended in patients with an estimated glomerular filtration rate (eGFR) of 30-60 mL/min/1.73 m 2 , it is contraindicated for use in patients with an eGFR of less than 30 mL/min/1.73 m 2 (123)
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however, in inflammatory disease states, particularly when intestinal barrier integrity and function may be compromised, LPS can enter the circulation, where it can activate TLR4 on inflammatory cells and trigger a systemic inflammatory response
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