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Medication adjustment: If gastrointestinal side effects are contributing to back discomfort, discuss with your healthcare provider about slowing the titration schedule or temporarily holding at a lower dose until adaptation occurs

The metabolic complications induced by APs had initially been attributed to weight gain, which is a common side effect and key co-determinant in AP-induced metabolic dysfunction (Townsend et al., 2018)

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Class III: high solubility, low permeability

However, even in large real world cohorts of patients with T1D on GLP-1RA, low rates of hypoglycemia were observed ( ADJUNCT ONE and TWO trials, the 2 largest studies with GLP-1RA in T1D, reported increased rates of hypoglycemia