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Symptom Red Flags Report these to your prescriber promptly: worsening fatigue despite adequate sleep (possible copper-deficiency anemia), tingling or numbness in the feet (peripheral neuropathy from copper deficiency), new or worsened insomnia (possible alkaline-urine effect extending amphetamine half-life), or a perceived loss of Adderall XR efficacy (possible pharmacodynamic blunting)

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