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Absolute contraindications to GLP-1 receptor agonists include: Personal history of medullary thyroid carcinoma Family history of medullary thyroid carcinoma Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Pregnancy (for weight management indications) Severe gastrointestinal disease, including gastroparesis Patients should be specifically questioned about these conditions during pre-treatment evaluation

Antifungal peptides as therapeutic agents

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Yes, both medications are FDA-approved for weight management in individuals with obesity or weight-related conditions, even if they do not have diabetes

In particular, people with hypothyroidism have the potential to take more thyroid hormone than they need for a number of reasons