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When the combination of sitagliptin and metformin immediate-release was coadministered with a sulfonylurea or with insulin, the percentage of patients reporting at least one adverse reaction of hypoglycemia was higher than that observed with placebo and metformin immediate-release coadministered with a sulfonylurea or with insulin (Table 3)

12.3 Pharmacokinetics Sitagliptin The pharmacokinetics of sitagliptin have been extensively characterized in healthy subjects and patients with type 2 diabetes mellitus

Large randomized trials, including the SUSTAIN and SELECT studies, tracked cardiovascular events across thousands of patients

Andriole GL, Kirby R

However, as their use has skyrocketed, emerging research suggests that some individuals may be at risk for unexpected complications, including serious vision problems