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The postprandial glucose control mediated by the short-acting GLP-1 RA seems to be primarily explained through the delaying effect on gastric emptying rather than the effect on insulin and glucagon secretion
Researchers found that hexarelin treatment significantly improved glucose tolerance and reduced plasma and liver triglycerides in insulin-resistant mice
Di Tomo P, Lanuti P, Di Pietro N, Baldassarre MPA, Marchisio M, Pandolfi A, et al
Appreciating the triple agonist action helps explain why retatrutide might succeed in people that have done poorly on other therapies
For instance, dimethyl fumarate (DMF) serves a role in reducing neuroinflammation and ferroptosis by regulating the NF-B signaling pathway (23)
