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Ca-AKG plays a role in mitochondrial energy metabolism and has been studied in relation to biological aging pathways and cellular health

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Furthermore, GLP-1RA treatment in patients with T2DM has been linked to decreased secretion of pro-inflammatory cytokines, such as interleukin-1 (IL-1), interleukin-6 (IL-6) and tumor necrosis factor- (TNF-) by peripheral blood mononuclear cells (PBMC) [75]