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The primary difference is bioavailability

Sometimes another treatment is likely to be a better fit

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There is no established upper limit for B12 intake due to its low risk of toxicity

Yang et al., 2019), disturbed action potentials (Yang et al., 2019), as well as impaired neurite extension and increased mitochondrial biogenesis as a compensatory strategy to counteract the defective phenotype induced by LHON mutations (Wu et al., 2018)