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Retatrutide is an investigational peptide compound studied for its interaction with three major metabolic receptor pathways: GLP-1 Glucagon-Like Peptide-1 receptor GIP Glucose-Dependent Insulinotropic Polypeptide receptor Glucagon receptor The combination of these three pathways makes Retatrutide an important subject of research into metabolic signalling, energy balance, glucose regulation and body-weight regulation

Retatrutide adds glucagon receptor agonism, which may contribute to increased energy expenditure, enhanced hepatic lipolysis, and liver fat reduction mechanisms absent from Tirzepatides profile

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