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This creates a rational decision for IP teams: reduce investment in late-stage secondary patent filings for small-molecule drugs and redirect that IP budget toward earlier-stage patents (where the compound is still within its pre-negotiation window) or toward biologic assets (where the 13-year clock preserves the value of secondary patents in years 9-13)
Maisch GmbH, Ammerbuch, Germany)
Beyond the obesity indication, they are studying retatrutide for type 2 diabetes (TRIUMPH-2), obstructive sleep apnea (TRIUMPH-3), and cardiovascular outcomes
Alternative treatments include SGLT2 inhibitors (dapagliflozin, empagliflozin), DPP-4 inhibitors (sitagliptin), metformin, sulfonylureas, or insulin therapy
Healthy fats from avocados, nuts, seeds, and olive oil support satiety and brain function
