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The two pathways converge on GH release but through different intracellular cascades, which is why combining a GHS-R1a agonist (like ipamorelin) with a GHRH analog (like CJC-1295) produces a synergistic rather than merely additive GH response

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At the same SA concentration, cell viability (Q4 represents viable cells) in the MSN-ss-SA treatment (92.8%) was slightly lower than the water control (93.4%) but higher than the SA treatment (92.1%)