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After treatment initiation and dose increases, patients should be observed carefully for signs and symptoms of pancreatitis (including persistent severe abdominal pain, sometimes radiating to the back and which may or may not be accompanied by vomiting)

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Permanent hair reduction is defined as the long-term, stable reduction in the number of hairs re-growing when measured at 6, 9, and 12 months after the completion of a treatment regime,\u201d as well as treatment of benign pigmented lesions (sun spots and brown spots), wrinkles, and vascular lesions (such as port-wine stains, hemangiomas, telangiectasias)