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Nasal mucosa abnormalities (such as scarring and edema) due to chronic administration, or due to other causes (nasal blockage, nasal mucosal atrophy, severe atrophic rhinitis, recent nasal surgery such as transsphenoidal hypophysectomy) may cause erratic, unreliable absorption

I imagine weight loss and A1C outcomes will be similar but the extra metabolic benefits may be the key

Integration with established treatment approaches rather than replacement of proven therapies represents a prudent approach pending definitive clinical validation

doi: 10.3389/fphar.2023.1101452 82 CooperJ

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