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In addition, in PCOS rat models, metformin also improves hormonal balance by upregulating the phosphatidylinositol 3-kinase (PI3K) pathway, further demonstrating its multifaceted action on IR and metabolic dysregulation ( 2.2 Effects of metformin on inflammation in PCOS PCOS has been recognized as a low-degree chronic inflammation disease, evidenced by elevated cytokine levels and macrophage infiltration
These modifications result in a longer half-life (approximately 2030 hours) and reduced binding to IGF-binding proteins, making it about three times more potent than native IGF-1
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It's a synthetic peptide consisting of 15 amino acids, derived from a larger protective protein naturally found in human gastric juice
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