What clinical evidence supports tirzepatide's dual mechanism
Collectively, these results affirmed that hepsin plays a crucial role in regulating GJ communication, which in turn impacts oxidative stress
J Diabetes Investig 11:400404 Batzias K, Antonopoulos AS, Oikonomou E, Siasos G, Bletsa E, Stampouloglou PK, Mistakidi CV, Noutsou M, Katsiki N, Karopoulos P, Charalambous G, Thanopoulou A, Tentolouris N, Tousoulis D (2018) Effects of Newer Antidiabetic Drugs on Endothelial Function and Arterial Stiffness: A Systematic Review and Meta-Analysis
These shifts can leave the body feeling more fatigued as it adapts to the drug
The peptide may have lost potency