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Synthesis and characterization

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After coronary artery ligation in mice, intraperitoneal T4 treatment upregulated cardiac ILK and Akt activity, enhanced early myocyte survival, and improved cardiac function establishing the mechanistic basis for the broader tissue-repair claims associated with thymosin beta-4 and its 1723 fragment TB-500

Increased GSTP1 expression has been reported in pre-neoplastic lesions in chemically induced animal cancer models (Satoh et al, 1985) and in many human tumours, relative to surrounding normal tissues (Shea et al, 1988)