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However, both drugs independently reduce appetite and fluid intake, creating an additive risk for dehydration, electrolyte imbalances, and acute kidney injury in vulnerable populations

Bile acids also play a major role in shaping the gut microbiome

From a broader perspective, this work challenges the traditional dogma that GPCRs activate single canonical pathways

Maintaining protein intake supports both outcomes simultaneously

Medicare Advantage beneficiaries are also less likely to receive newer antihyperglycemic therapies with proven outcome benefits in high-risk individuals. They added that these findings reinforce the need for surveillance of long-term outcomes under various Medicare plan structures and for program evaluation to ensure that indicated but more costly care is not stinted among at-risk beneficiaries under managed care approaches