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Although the fluorine atom is not a very effective XB donor, it can exhibit a positive -hole when bound to another fluorine atom or attached to O, N, C, or other atoms that possess strong electron-withdrawing substituents (Wilcken et al., 2013)

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CD is characterized by transmural inflammation that can affect the entire gastrointestinal tract, often presenting with specific phenotypes such as stricturing, inflammatory, or perianal disease

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