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For individuals with severe obesity (BMI 40 kg/m or 35 kg/m with comorbidities) who have not achieved adequate weight loss with non-surgical methods, bariatric surgery represents an evidence-based option

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Additionally, GLP-1R reduces triglyceride and LDL cholesterol levels, decreases adipose tissue inflammation and minimizes the formation of ectopic fat deposits, promoting overall metabolic health [4]

P.SciarrettaS.YabutaN.NojimaH.et al (2014)

These effects are dose-dependent and tolerance develops within 714 days of consistent dosing, but starting too high causes protocol abandonment before pigmentation results become visible