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However, as opposed to adult humans, where IGF-2 levels are substantial, systemic IGF-2 levels are undetectable in adult rodents

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The overexpression of -syn promotes CCR2 + monocyte infiltration into the CNS, exacerbating inflammation and neurodegeneration and placing CCL2-mediated recruitment within broader -syn-driven inflammatory cascades rather than isolated chemokine signalling [28]