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Tretinoin 0.05 % is more concentrated than tretinoin 0.025 %, therefore tretinoin 0.025 % is typically used as a starting point to minimize irritation
17(36):4462-81 Melatonin: An Established Antioxidant Worthy of Use in Clinical Trials Ahmet Korkmaz, et al Mol Med 2009 Jan-Feb
Research shows it reduces pro-inflammatory cytokines such as TNF- and IL-6, which are central drivers in acne pathogenesis (Pickart et al., 2015)
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