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They could have off-target negative health effects, and it will be years before we know if they have the same kind of positive effects on long-term heart and kidney health as semaglutide and tirzepatide. But there may also be unanticipated benefits beyond easier use

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( c ) Sum of all % abundance histone methylation marks divided by total number of histone methylation marks (31) in the indicated cells normalized to control (n = 6 technical replicates from 2 independent experiments)

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These effects are generally short-term

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