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Chiechio S et al
Ballard, F.J., et al., Effects of interactions between IGFBPs and IGFs on the plasma clearance and in vivo biological activities of IGFs and IGF analogs
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On the one hand, the BBB prevents macromolecules such as albumin, prothrombin, and plasminogen from entering the CNS, preventing apoptosis and damage to neural tissue (53, 54)
Ischemic injury activates the classical, alternative, and MBL pathways, leading to the release of complement degradation products such as C3a and C5a
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