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Biological preventive and therapeutic experiments were conducted, where laboratory rats were divided into 6 groups, the first group G1 (positive control group), the second group G2 (negative control group), the third group G3 preventive experiment 1 (group glutathione extracted from spinach + CCl4), the fourth group G4 therapeutic experiment 1 (Group CCl4+ Glutathione extracted from spinach), the fifth group G5 Preventive experiment 2 (Group of synthetic glutathione + CCl4), the sixth group G6 therapeutic experiment 2 (Group CCl4+ Glutathione extracted from spinach)
Initial dose: 2.5mg, which may be gradually increased to 5mg, 7.5mg, 10mg, 12.5mg, or 15mg
Statistical analysis Treatment and data analyses were blinded by masking sample labels
Quick Answer: Neither is objectively "better" because they serve different functions
In osteoblasts, ferroptosis is prevented by the Nrf2/heme oxygenase 1 (HO-1) pathway via activating HO-1, which upregulates GPX4 through regulation of antioxidant-responsive elements (ARE)- dependent genes (14, 15)
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