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There are eight types of GPX family in mammals (GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GPX8), of which GPX1-4 and GPX6 of mammals are considered to be selenoproteins containing selenium, which have antioxidant functions, and GPX6 is only expressed in the human body ( In mammals, GPX works with superoxide dismutase and catalase to form an enzymatic antioxidant system that reduces reactive oxygen species (ROS) and limits their toxicity

The dysregulation of these diverse RCD pathways is not only extensively documented in cellular and animal models ( Table 2 ) but is also validated by transcriptomic and single-cell profiling of human clinical datasets

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Animal studies are quite impressive on the ability of melatonin to reduce amyloid-beta plaque and clear it from the brain