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Enrichment of Proteobacteria represents one of the most prominent microbiota features in DGE, with increased abundance positively correlating with the progression of DGE (Lin et al., 2024) reported an increased abundance of Proteobacteria, including Pseudomonas and Alkalibacterium , in patients with DGE

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Nuclear RPSA senses viral nucleic acids to promote the innate inflammatory response

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Third, clinical translation should include establishing multicenter HD biobanks to validate associations between ferroptosis biomarkers (such as cerebrospinal fluid ACSL4 levels and striatal iron MRI signals) and clinical measures (UHDRS scores and transcranial motor-evoked potentials)