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Protocol approach: frozen shoulder (adhesive capsulitis) Goal: Reduce capsular fibrosis, restore range of motion, manage pain Peptide approach: BPC-157: 300 to 500 mcg daily for anti-inflammatory and tissue healing properties TB-500: 500 to 750 mcg twice weekly for systemic anti-inflammatory and tissue remodeling Note on relaxin-2: While the most specifically targeted peptide for this condition, it remains largely in the research phase and is not widely available through standard channels Duration: Twelve to sixteen weeks (frozen shoulder has a prolonged natural course) Critical addition: Aggressive physical therapy within pain tolerance

The most clinically relevant combination is MOTS-c with metformin

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Anti-diabetic drugs repositionable as potential anti-cancer drugs Diabetes Mellitus (DM) is a chronic disease that occurs either when the pancreas does not produce enough insulin or when the body cannot effectively use the insulin it produces

Crucially, the researchers explored substituting these expensive growth factors with a small-molecule cocktail, specifically 10 g/mL Vitamin C, 0.1 M Dihexa, and 10 M Forskolin (VDF cocktail), to assess its efficacy in inducing hepatic specification