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Estrogen has been shown to upregulate endogenous MOTS-c expression in preclinical models, which may partly explain why metabolic deterioration accelerates in perimenopause when estrogen falls precipitously [2]

Protective effects of selenium on acetaminophen-induced hepatotoxicity in the rat.ToxicolApplPharmacol

However, the precise kinetics of selenium handover from Prx6 to SEPHS2, the structural determinants that govern selenium selectivity, and the extent to which Prx6 activity becomes rate-limiting during oxidative stress remain unclear

J Physiol 261:387422

Reduced B12 levels will also contribute to impaired digestion, as this nutrient plays an important role in optimal gut health