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In-depth mechanistic studies reveal that DCA primarily activates the Takeda G protein-coupled receptor 5 (TGR5) on the surface of intestinal epithelial and immune cells, triggering the NF-B signaling pathway and inducing the release of pro-inflammatory cytokines such as IL-1, IL-6, and TNF-, while simultaneously inducing ROS bursts that lead to DNA damage (Figure 2A)
BPC-157 for Injury Recovery and Musculoskeletal Health Another aging intervention Dr
Physiol Plant 116:96105 Cai Y, Cao F, Wei K, Zhang G, Wu F (2011) Genotypic dependent effect of exogenous glutathione on Cd-induced changes in proteins, ultrastructure and antioxidant defense enzymes in rice seedlings
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