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An enzyme called tyrosinase is needed to create melanin (the pigment that causes the brown spots) and while several other skin lightening agents work to inhibit the synthesis of tyrosinase itself (like vitamin C or licorice), arbutin lets tyrosinase be and rather hinders the melanin-forming activity of the enzyme
The formation of the Hp-Hb complex prevents Hb dimers from entering the glomerulus, and this complex is then taken up by CD163+ macrophages (Haymann et al., 2010
It is important to note that mitochondria are indispensable in all types of cell death, and consequently, in ASD pathogenesis
Siegers CP et al
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