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However, given the associated risks of cardiovascular disease and various cancers, the benefits of these medications, such as better glycemic control, weight loss and improvement in cardiometabolic risk factors as well as other obesity complications, appear to outweigh the risks for most adults with obesity [143, 153]

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Both medications enhance incretin hormone activity through overlapping mechanismsRybelsus directly activates GLP-1 receptors whilst Januvia preserves endogenous incretin hormones

doi: 10.1093/clinchem/29.4.629 16 WangCZhangRWeiXLvMJiangZ