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Despite this, side effects can be mitigated by careful dose titration
Biotin (vitamin B7) is an essential micronutrient that's best known for its role in the production of keratin, a key structural protein in you guessed it hair, skin and nails
Carlsson Petri KC, Ingwersen SH, Flint A, Zacho J, Overgaard RV
195,196,197 At the cellular level, this translates into a massive increase in cytoplasmic Na + concentration, membrane depolarisation and opening of voltage-gated Ca 2+ channels, which in turn promotes massive release of glutamate that results in even large depolarisation enlarging Na + and Ca 2+ influx thus completing the vicious circle of excitotoxic damage, as Ca 2+ overload triggers necrotic cell death
Its usually prescribed alongside diet and exercise to enhance overall glycemic management
