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Higher plant APR are homodimers with each monomer formed by an N-terminal domain binding a [4Fe-4S] cluster and bearing the APR activity and a C-terminal GRX-related domain (Figure 2 and Supplementary Table 2)

Its important to remember that while B12 injections can address fatigue related to deficiency, they are not a universal solution for tiredness caused by other medical or lifestyle factors

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Van Konynenburg, RA (April 21, 2012)