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Discontinuation rates due to adverse events were reported as low and single-digit across both REDEFINE 1 and 2, which Novo Nordisk highlighted as a positive tolerability signal given the drugs dual-mechanism approach
Those with more adipose tissue or slower initial response may benefit from increasing to 400-500mcg
Avoid repeated freezethaw cycles as they degrade peptides over time [11]
The dosing intervals of salmeterol have been changed to avoid potential ergogenic effects, though the maximum daily delivered dose remains the same
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