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Discontinuation rates due to adverse events were reported as low and single-digit across both REDEFINE 1 and 2, which Novo Nordisk highlighted as a positive tolerability signal given the drugs dual-mechanism approach

Those with more adipose tissue or slower initial response may benefit from increasing to 400-500mcg

Avoid repeated freezethaw cycles as they degrade peptides over time [11]

The dosing intervals of salmeterol have been changed to avoid potential ergogenic effects, though the maximum daily delivered dose remains the same

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