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Diabetes 55, S70S77
This emphasis on long-term behavioral and psychological support is further underscored by a recent BMJ systematic review and meta-analysis showing rapid and clinically meaningful weight regain after discontinuation of weight-management medications, with regain occurring faster than after behavioral weight-management programmes [97]
The benefits of weight loss go beyond improving glycemic control, including reducing cardiovascular risk factors, and improving health-related quality of life and common obesity-related comorbidities of T2D, such as osteoarthritis and sleep apnea [47]
For patients requiring additional glycemic lowering, the dose can be further up-titrated to 14 mg once daily after taking the 7 mg dose for at least 30 days
Patients should not adjust their antihypertensive medications without consulting their healthcare provider
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